Isoket Uses

Isoket is a brand name for isosorbide dinitrate, an organic nitrate used primarily as a vasodilator in the management of several heart conditions^[1].

Uses of Isoket include:

• Treatment of angina pectoris (chest pain due to reduced blood flow to the heart). Isoket is used to relieve angina, reducing both the frequency and severity of attacks^[1][2][3].
• Treatment of heart failure (especially left ventricular failure), including cases unresponsive to other treatments, and for symptoms such as shortness of breath or ankle swelling^[3][5].
• Management of acute myocardial infarction (heart attack) with left ventricular failure^[5].
• During surgical or diagnostic procedures on the heart, such as percutaneous transluminal coronary angioplasty, to facilitate prolongation of balloon inflation and to prevent or relieve coronary spasm^[5].

Isoket primarily works by widening blood vessels (vasodilation) in the heart and peripheral circulation, which improves blood flow to the heart muscle and reduces the heart’s workload^[7]. This mechanism leads to a reduction in both afterload and preload, decreasing left and right ventricular end-diastolic pressures^[7]. It also reduces the oxygen demand of the myocardium and increases oxygen supply to ischaemic (oxygen-starved) areas by redistributing blood flow^[7].

Isoket is typically administered intravenously for acute or hospital settings, with dosing adjusted to patient response^[3][5]. It is also used in emergencies and in intensive care for rapid action in critical conditions affecting the heart.

References

• [1] Isosorbide dinitrate: Uses, Interactions, Mechanism of Action – DrugBank
• [2] Isoket | Drug Information, Uses, Side Effects, Chemistry – PharmaCompass
• [3] ISOKET 0.5 MG/ML SOLUTION FOR INFUSION OR INJECTION – Drugs.com UK
• [5] Isoket 1 mg/ml concentrate for solution for injection or infusion – EMC
• [7] Isoket IV: Dosages and Ingredients | Full Prescribing Info – MIMS