Losaar Plus 50/12.5, which contains losartan 50 mg and hydrochlorothiazide 12.5 mg, is primarily used to treat high blood pressure (hypertension). It is also prescribed to reduce the risk of stroke in people with high blood pressure and left ventricular hypertrophy (a type of heart problem), and may be used to protect the kidneys in people with type 2 diabetes who have nephropathy (kidney disease)[2][3][7].
Losartan works by blocking the action of angiotensin II, a chemical in the body that causes blood vessels to tighten, thereby allowing blood vessels to relax and lower blood pressure. Hydrochlorothiazide is a diuretic (sometimes called a “water pill”) that helps the body get rid of excess salt and water through urine, further aiding in reducing blood pressure[7].
The combination is often used when a single medication alone does not adequately control blood pressure, or as initial therapy in cases of severe hypertension where rapid control is necessary[2].
Other potential uses, always under a doctor’s supervision, include helping to protect kidney function in certain patients and lowering the risk of cardiovascular events in those with specific high-risk features[2][3].
References
- [1] How and when to take losartan – NHS
- [2] Hydrochlorothiazide / Losartan Dosage – Drugs.com
- [3] Losartan: Uses, Interactions, Mechanism of Action | DrugBank Online
- [4] Cozaar (Losartan) Dosages for Adults and Children – GoodRx
- [5] Losartan (Cozaar, Arbli) – Uses, Side Effects, and More – WebMD
- [6] losartan 50 mg-hydrochlorothiazide 12.5 mg tablet
- [7] Losartan/Hydrochlorothiazide (Hyzaar) – Uses, Side Effects, and More
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