LP299v, also known as Lactiplantibacillus plantarum 299v, is a probiotic strain extensively documented for its health benefits, particularly in the area of gastrointestinal health[2][3][5]. Its primary uses include:
- Alleviating symptoms of Irritable Bowel Syndrome (IBS): Clinical studies indicate that LP299v significantly reduces global IBS symptoms, such as abdominal pain, flatulence, diarrhea, constipation, urgency, and the feeling of incomplete evacuation. Long-term usage (up to 12 weeks) was found to improve quality of life and was well tolerated by the majority of patients[6][5].
- Improving general gut health: LP299v can reduce flatulence and abdominal pain by modulating gut microbiota, supporting intestinal barrier function, and producing beneficial metabolites. Its capacity to adhere to the intestinal epithelial cells enhances its probiotic effects and intestinal colonization[2][5][7].
- Enhancing iron absorption and status: Several clinical studies have shown that LP299v can positively affect iron absorption and iron status, which may aid individuals with iron deficiency or those at risk[5].
- Reducing inflammation and supporting metabolic health: Evidence from clinical trials shows benefits in reducing inflammation and improving certain metabolic markers, with potential applications in broader metabolic and inflammatory conditions[2][3].
- Cognitive and affective function support: A clinical trial found that LP299v supplementation in patients with major depressive disorder led to decreased kynurenine concentration and improvements in cognitive performance when combined with standard treatments[1].
The strain is robust, remains viable during gastric transit, is stable in freeze-dried form, and is used in various consumer health products, including capsules, tablets, and food supplements. Its safety profile is well established and it is approved for a wide range of dietary and clinical applications worldwide[2][3][5][7].
References
- [1] Probiotic Lactobacillus Plantarum 299v decreases kynurenine concentration and improves cognitive functions in major depression
- [2] LP299V® probiotic strain with unique health benefit
- [3] Lactiplantibacillus plantarum 299v (LP299V®) (DSM 9843)
- [5] Lactiplantibacillus plantarum 299v (LP299V®)
- [6] Treatment of IBS with Lactobacillus plantarum 299v: a non-interventional study
- [7] Lactiplantibacillus plantarum 299v (LP299V®): three decades of probiotic research and clinical experience
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