Stilnox (zolpidem) is primarily prescribed for the short-term treatment of insomnia, helping individuals who have difficulty falling asleep or staying asleep[1][2][3]. It is intended to improve sleep onset and maintenance by enhancing sleep quality, decreasing the time to fall asleep, lengthening sleep duration, and reducing nocturnal awakenings[1][2][5].
According to clinical guidelines, zolpidem should be considered only after non-pharmacological interventions, such as cognitive behavioral therapy for insomnia and sleep hygiene, have been attempted[2]. It is recommended for short-term use, typically two to six weeks[2], and administered at the lowest effective dose due to potential side effects and the risk of dependence[2][3].
Primary and off-label uses include:
- Short-term treatment of insomnia in adults, especially for difficulties in sleep initiation and maintenance[1][2][3][5][6].
- Special circumstances: Off-label, zolpidem has been observed to improve brain function in some patients in a vegetative state after brain injury, potentially reversing abnormal brain cell metabolism[1].
Zolpidem is available in several oral dosage forms, including conventional tablets, extended-release tablets, sublingual tablets, and oral sprays[1][3]. Dosing varies based on gender and specific patient factors, with lower doses generally recommended for women due to slower drug clearance[1][4].
Careful assessment is recommended if insomnia persists after 7 to 10 days of use to rule out underlying medical or psychiatric conditions[1]. Zolpidem use is not advised for elderly patients, and caution is required due to risks such as daytime drowsiness, driving impairment, memory issues, and other adverse effects[2][4].
References
- [1] Zolpidem – StatPearls – NCBI Bookshelf
- [2] Zolpidem – Wikipedia
- [3] Zolpidem: Uses, Side Effects, Interactions, Pictures – WebMD
- [4] Zolpidem (oral route) – Side effects & dosage – Mayo Clinic
- [5] Zolpidem: Uses, Interactions, Mechanism of Action | DrugBank Online
- [6] Zolpidem: medicine used for sleeping problems (insomnia) – NHS
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