Targinact 20Mg/10Mg Uses
Targinact 20mg/10mg is a widely prescribed medication designed to manage severe, persistent pain and address opioid-induced constipation. Understanding its uses, benefits, and considerations can help patients, caregivers, and healthcare professionals make informed decisions about treatment. This article dives deep into the medical uses of Targinact, how it works, and what users need to know for safe and effective care.
Essential Highlights
- Targinact 20mg/10mg combines oxycodone and naloxone for the management of severe pain, especially when other treatments have failed.
- Oxycodone provides strong pain relief, while naloxone reduces opioid-induced constipation.
- Targinact is used for chronic pain and as a second-line therapy for severe idiopathic Restless Legs Syndrome (RLS).
- The medication is not suitable for mild or acute pain, and must be used under strict medical supervision.
- Extended-release tablets are taken every 12 hours and must be swallowed whole—never crushed or chewed.
- Further details and related resources are available on Uses.co.za and the dedicated Targinact 20mg/10mg Uses page.
Table of Contents
What is Targinact 20Mg/10Mg?
How Does Targinact Work?
Primary Uses and Indications
Dosage and Administration
Safety, Side Effects, and Precautions
Frequently Asked Questions (FAQ)
What is Targinact 20Mg/10Mg?
Targinact 20mg/10mg is a prolonged-release combination tablet containing two key ingredients: oxycodone and naloxone.
- Oxycodone: A potent opioid analgesic, providing relief for moderate to severe pain.
- Naloxone: An opioid antagonist that helps counteract the constipating effects of oxycodone, acting locally in the gut.
This formulation is designed for individuals who require continuous, around-the-clock pain management and are at risk of experiencing opioid-induced constipation[1][3][5]. It is not intended for short-term pain or occasional “as-needed” use.
Further details can be found on the official Targinact Uses page.
How Does Targinact Work?
Targinact’s dual-action formula offers both pain relief and improved gastrointestinal tolerability.
- Oxycodone binds to opioid receptors in the brain and spinal cord, dampening pain signals for effective analgesia[3][7].
- Naloxone, included in a lower dose, blocks opioid receptors in the gut—minimizing constipation but not interfering with oxycodone’s action in the brain.
“The aim of this combination is to reduce the likelihood of constipation with oxycodone. Naloxone is added to counteract opioid-induced constipation by blocking the action of oxycodone at opioid receptors locally in the gut.”[7]
This targeted effect helps maintain patient quality of life and can eliminate the need for separate laxatives[7].
Primary Uses and Indications
Targinact 20mg/10mg is primarily indicated for:
- Chronic, severe pain: When pain is severe enough to require daily, around-the-clock opioid therapy, and other treatments have proven inadequate[1][3][5].
- Severe idiopathic Restless Legs Syndrome (RLS): It is used as a second-line treatment in adults who have not responded to dopaminergic therapy, particularly if RLS symptoms are persistent (present for at least 6 months, occurring most days)[1].
Common scenarios for Targinact use include:
– Cancer-related pain
– Neuropathic pain
– Pain following major surgery or injury, where long-term opioid management is necessary
Learn about more medicinal uses of various products at Uses.co.za.
Dosage and Administration
Targinact 20mg/10mg should be taken exactly as prescribed and never adjusted without consulting a healthcare provider.
- Tablets are typically taken every 12 hours (morning and evening), with or without food[5].
- Always swallow the tablets whole with a full glass of water. Do not crush, chew, or break the tablets, as this can cause rapid release and potential overdose.
- Dosage is tailored to the patient’s clinical needs and response to therapy. The maximum recommended dose is usually Targinact 40mg/20mg twice daily, but higher doses require specialist oversight due to reduced effectiveness of naloxone for constipation prevention[5].
Always follow the guidance provided by your doctor and pharmacist to avoid complications.
Safety, Side Effects, and Precautions
Targinact is a strong medication and must be used responsibly to minimize risks.
Potential side effects include:
– Common: Nausea, vomiting, drowsiness, dizziness, dry mouth, sweating, and mild constipation[3][5][7].
– Serious: Respiratory depression, allergic reactions, low blood pressure, confusion, and withdrawal symptoms.
Precautions and Contraindications:
– Not suitable for acute or mild pain, those under 18, pregnant or breastfeeding women, or patients with severe liver dysfunction, severe asthma, head injuries, or a history of seizures or alcoholism[3].
– Do not use if you are allergic to any of the ingredients or are currently being treated for narcotic withdrawal.
– Caution should be exercised if you are taking other medications, particularly MAO inhibitors.
If you experience any unusual symptoms or side effects, seek immediate medical attention.
Frequently Asked Questions (FAQ)
1. What conditions is Targinact 20mg/10mg prescribed for?
Targinact is used for chronic, severe pain and as a second-line treatment for severe idiopathic Restless Legs Syndrome (RLS) when other therapies are ineffective.
2. How does Targinact differ from standard oxycodone?
Targinact combines oxycodone with naloxone, which specifically helps reduce opioid-induced constipation—a common side effect of long-term opioid use[7].
3. Can I use Targinact for sudden, short-term pain?
No, Targinact is only for ongoing, chronic pain that requires continuous management. It is not suitable for “as-needed” use[3].
4. What should I do if I miss a dose?
Take the missed dose as soon as you remember unless it’s close to your next scheduled dose. Never double up to make up for a missed dose. Consult your healthcare provider for guidance.
5. Are there any foods or medications to avoid while taking Targinact?
Discuss all other prescriptions, over-the-counter drugs, and supplements with your doctor. Avoid alcohol and certain medications like MAO inhibitors that may interact with Targinact[3].
6. How do I store Targinact safely?
Store in a secure place, away from children and pets, and keep at room temperature as directed by your pharmacist.
7. Where can I find more information on Targinact and its uses?
Visit the Targinact 20mg/10mg Uses page, the main Uses.co.za website, and the NHS resources on Targinact.
For further trusted information, also explore:
– NHS UK – Oxycodone and Naloxone Information
– Drugs.com Targinact Overview
– MedlinePlus Opioid Safety
For in-depth details on medication uses, visit Uses.co.za. Always consult your healthcare provider for personal medical advice.
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