Urizone Uses

Urizone is used to treat urinary tract infections (UTIs) and cystitis (bladder infection) in women, men, and female children over the age of five years^[1]. The primary indication is for the treatment of acute uncomplicated lower urinary tract infections caused by sensitive Escherichia coli (E. coli), particularly in women and female children above five^[2]. Additionally, Urizone is indicated for prophylaxis in diagnostic and surgical transurethral procedures in adult men^[2].

As an antibiotic preparation of fosfomycin trometamol, Urizone is administered orally and achieves high concentrations in urine for at least 36 hours after a single dose^[2]. This extended duration in the urinary tract makes it effective for single-dose therapy

• Primary uses:
  • Treatment of acute uncomplicated lower urinary tract infections (UTIs) in women and female children over 5 years due to susceptible E. coli^[2][3][4]
  • Treatment of cystitis (bladder infection) in women, men, and eligible children^[1][7]
  • Prophylaxis for adult men during diagnostic and transurethral surgical procedures^[2]

Urizone is only available with a doctor’s prescription and should not be used in individuals with a known allergy to fosfomycin or any of the product’s ingredients. It is also contraindicated in patients with severe renal insufficiency (creatinine clearance < 10 ml/min)^[1][2]. Safety and efficacy in children under five years and in women under the age of 18 have not been established^[1][8].

When planning to use Urizone, it is important to inform the healthcare provider about other existing medical problems, especially kidney disease, as altered kidney function may impact the drug’s clearance from the body^[1]. Urizone’s absorption is reduced if taken with food, so it is often recommended to take it on an empty stomach^[2].

Urizone (fosfomycin) is classified as a broad-spectrum bactericidal antibiotic, meaning it acts against a wide variety of bacteria, including multidrug-resistant strains^[4]. However, its use is limited to uncomplicated UTIs and is not recommended for pyelonephritis, perinephric abscess, or complicated infections^[5][8].

References

• [1] Patient Information Leaflet – URIZONE
• [2] URIZONE 2 g and 3 g Granules (Prescribing Information)
• [3] Fosfomycin – Side Effects, Dosage, Precautions, Uses
• [4] Fosfomycin: Uses, Side Effects, Dosages, Contraindications
• [5] Fosfomycin: Uses, Interactions, Mechanism of Action – DrugBank
• [7] Urizone (fosfomycin): uses & side-effects
• [8] Fosfomycin Dosage Guide + Max Dose, Adjustments