Sulpiride is an antipsychotic medication primarily used for the treatment of schizophrenia and other mental health conditions[1].
- Schizophrenia: Sulpiride’s main clinical use is to manage symptoms associated with acute and chronic schizophrenia, either as monotherapy or in combination with other treatments for cases of treatment resistance[1][3][5].
- Major Depressive Disorder and Dysthymia: It is sometimes prescribed at low doses to treat dysthymia and as add-on therapy for major depressive disorder, particularly in Japan[1].
- Anxiety and Panic Disorders: Low-dose sulpiride has demonstrated efficacy for anxiety and refractory panic disorder[1][5].
- Vertigo and Dyspepsia: In some countries, sulpiride is indicated for treating vertigo and, in combination, as a symptomatic treatment for dyspepsia (indigestion)[3].
- Other Psychiatric Indications: Sulpiride has also been used to treat short-term severe behavioral disorders in children (including agitation, self-harm, and repetitive actions), Tourette syndrome, autism spectrum disorder, and other psychiatric symptoms such as obsessive-compulsive disorder and personality disorders[5][7].
- Other Potential Uses: Sulpiride has been investigated in clinical research for use in menopausal syndrome (hot flashes), as an antiemetic for nausea/vomiting, and for mood regulation through selective dopamine D2 antagonism[4].
Sulpiride is not approved for use in the United States, Canada, or Australia, but is commonly prescribed in Asia, Europe, Central and South America, and South Africa[1][7].
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