Azathioprine is an immunosuppressive medication primarily used to prevent organ rejection after a kidney transplant and to treat rheumatoid arthritis, especially when other treatments have not been effective[1][2][3][7].
It is also prescribed for several other immune-mediated conditions. Common uses of azathioprine include:
- Prevention of kidney transplant rejection (as an adjunct to other immunosuppressants)[1][2][3][7]
- Management of active rheumatoid arthritis[1][2][3][7]
- Treatment of Crohn’s disease and ulcerative colitis (inflammatory bowel diseases)[4][6]
- Management of skin conditions and systemic lupus erythematosus (lupus)[6]
- Treatment of other autoimmune disorders such as multiple sclerosis (off-label use), immune thrombocytopenia, and lupus nephritis[4][5][6]
Azathioprine is usually taken orally in tablet form—common tablet strengths are 25 mg, 50 mg, 75 mg, and 100 mg[1][7].
It works by decreasing the activity of the body’s immune system, thereby reducing immune attacks against transplanted organs or the patient’s own tissues in autoimmune diseases[1][3]. As a result, close medical supervision is required, since it can increase the risk of infections and, rarely, certain cancers[1].
References
- [1] Azathioprine (Imuran, Azasan) – Uses, Side Effects, and More | WebMD
- [2] IMURAN (azathioprine) – FDA Prescribing Information
- [3] Azathioprine: MedlinePlus Drug Information
- [4] Azathioprine: Uses, Interactions, Mechanism of Action | DrugBank
- [5] Azathioprine (Imuran) – Cleveland Clinic
- [6] Azathioprine: a medicine for conditions affecting the immune system | NHS
- [7] Azathioprine Uses, Side Effects & Warnings | Drugs.com
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